HIGH THROUGHPUT NATURAL PRODUCT DISCOVERY



A technical article from Genevac is available that details how its HT-24 centrifugal evaporation system is assisting a commercial flavours and fragrance company in its quest to find and isolate novel flavour ingredients from nature. Natural product derived discovery of novel flavour molecules is a highly complex process. Natural product sources yield complex extracts containing many components, which often do not lend themselves to processing and analysis. Conventionally, many steps of fractionation and evaluation are necessary until a compound is obtained from natural sources at the purity required for structural analysis. In the article a state of the art fractionation process using a Sepbox® Preparative HPLC - SPE system and a Genevac® HT-24 centrifugal evaporator is described. The Sepbox enables two dimensional, preparative scale fractionation of natural products using high performance liquid chromatography – solid phase extraction (HPLC-SPE). In sequ ...
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