MARTA RULL*, CRISTINA DAVI, ELENA CAÑADAS, WIM VAN DEN NEST, RAQUEL DELGADO
*Corresponding author
Lipotec S.A.U. Pol. Ind. Camí Ral. Isaac Peral, 17. 08850 Gavà, Spain

Abstract

Pollution is one of the main concerns nowadays, due to its multiple negative effects on health in many ways. The exposure to pollution and other negative factors like UV that almost everybody suffers every day alters the first protecting barrier that is the skin. The negative effects include the formation of reactive species and oxidative stress, leading to alteration of proteins, lipids and DNA. Consequently, the skin is damaged and some undesired visible signs appear. To prevent this premature skin aging, a stable and powerful antioxidant with a double scavenging activity (ROS and RNS) was evaluated. The following in vitro studies showed the efficacy of Dimethylmethoxy Chromanol in protecting cells from pollution and UV radiation which alter skin cells and functionality.

INTRODUCTION

Due to the growing increase of industrial activity during the last decades, air pollution is a current problem nowadays. It is a worrying environmental and public health concern especially exacerbated in the regions where highly populated and large cities are located.
The damaging substances mainly derived from the combustion of fossil fuels and cigarette smoke are the main constituents of air pollution, despite cigarettes contribute in a smaller scale but closer to the skin. Understood as extremely reactive species that can easily convert into other harmful compounds, sulfur oxides, nitrogen oxides, carbon monoxide, ozone, heavy metals and organic aerosols are the major air pollutants. Found among these compounds that damage the skin, particulate matter (PM), reactive oxygen species (ROS) and reactive nitrogen species (RNS) need to be particularly considered.
Due to its function as the interface between the body and the environment, the skin is constantly exposed to harmful external agents that induce the generation of free radicals and other highly reactive chemicals. These effects translate into extrinsic aging of the sk ...