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THE CHEMICAL ROUTE IS NOT THE ISSUE
Organometal reactions, such as Grignard and Organolithium reactions are known since long in academia and are a proven versatile method in organic chemistry to generate CC bonds. Meanwhile many Organolithium compounds are commercially available so that they don’t need to be synthesized on site any more. Although transportation and storage of these Organolithium intermediates is quite challenging, the number of their applications and total consumption hence increases continuously. Whereas the synthesis routes based on Organolithium intermediates at laboratory scale, even at low temperatures down to -80 ... ...