Belyntic’s Peptide Easy Clean (PEC) technology offers a simple tool to catch the target peptide from its crude mixture selectively – automated and parallel, for best-in-class high-throughput manufacturing and fast synthesis of purified peptide libraries. 

Peptide purity is often critically affected by co-eluting side products that are hard to remove by chromatographic methods. These impurities are problematic for the manufacturing of peptide APIs and lead to false-positive and false-negative results during R&D activities. The latter becomes especially relevant when the time for single synthesis optimizations, for example in peptide libraries, is not given. PEC is based on catch-and-release principles to purify the peptide of interest chemo-selectively.  

The PEC technology allows the automated processing of peptide purification in a 96 well-plate format, enabling easy access to purified peptide libraries. PEC’s strength becomes apparent in this particular case since high-quality peptides can be obtained in unprecedented times and at a low cost. Most peptidic impurities that may cause false-positive or -negative signals are removed, and reliability of subsequent screening or validation assays is greatly enhanced. These PEC-grade peptide libraries show excellent performance in, for example, validation studies of SARS-CoV-2 vaccine candidates. 

Belyntic offers PEC implementation services and kit products for peptide manufacturers, pharma, and biotech companies. Read more on https://belyntic.com