Abstract

Flow chemistry is an increasingly being studied technology which offers many opportunities to enhance a broad range of chemical processes, offering a wide versatility in applications (1).
This section focuses on flow chemistry potential, featuring recent studies on several areas of application: from synthesis to scale-up, quality analysis and crystallization.
Abstracts from articles of interest were retrieved researching on scientific online resources, like Google Scholar and Pubmed, and the selection was made from year 2023 to year 2024 with the following keywords: flow chemistry applications, flow chemistry synthesis, flow chemistry scale-up, quality control continuous production, crystallization in continuous flow.

SYNTHESIS

1) Selective Hydrogenation Reaction: Utilizing a Microreactor for Continuous Flow Synthesis of Nickel Nanoparticles

Introduction: In this investigation, we employed a continuous flow reactor to synthesize nickel (Ni) nanoparticles exhibiting uniform size distribution and excellent stability. Our focus centered on exploring the impact of reactant dilution and flow rate on the synthesis process.

Result: It was observed that the optimization of these parameters played a pivotal role in obtaining small-sized Ni nanoparticles. Specifically, we achieved successful synthesis using a solution of 0.00025 M NiCl2·6H2O and 0.002 M NaBH4, with a flow rate of 25 mL/h. The resulting Ni nanoparticles were effectively coated with the CTAB surfactant, as confirmed through thorough analysis using TEM and PSD techniques. Additionally, the interaction between the surfactant and nanoparticles was verified via FTIR analysis. We subjected them to high-pressure alkene hydrogenation to assess the catalytic activity of the synthesized Ni nanoparticles.

Method: Encouragi ...