Increasing regulatory and social requirements call for sustainable and renewable chemistry. For cosmetic products, CMR free chemistry has become a priority in a market more and more focused on natural products and particularly sensitive for the application of potentially hazardous substances. Molecular Hiving TM allows the synthesis of peptides without the use of solvents and reagents which are carcinogenic, mutagenic, or toxic to reproduction (CMR substances). This makes peptide products manufactured by this technology highly attractive for the pharmaceutical and cosmetics industry.
Molecular Hiving™ is a tag-assisted liquid-phase peptide synthesis technology developed by Professor Kazuhiro Chiba at Tokyo University of Agriculture and Technology. This technology uses a hydrophobic tag, which is applied in the same way as the resin for solid-phase peptide synthesis (SPPS) processes. The same standard Fmoc amino acid derivatives as for SPPS are applied for assembling the peptide chain. However, all couplings and cleavages of the Fmoc protecting group are performed in solution allowing for fast reactions and direct in-process controls, e.g. by HPLC. Excess reagents as well as coupling and cleavage related by-products are solely removed by aqueous extractions. Therefore, intermediate isolation of the tag-bound peptide and excessive washing steps are not required for Molecular Hiving™ technology.
Bachem und Jitsubo have signed an exclusive Licensing Agreement for Jitsubo’s Molecular Hiving™ technology. The results show that it is always possible to improve and adapt actual processes according to new regulatory requirements and respect economic, social, and environmental factors at the same time.
To learn more about the individual steps for synthesis of peptides applying Molecular Hiving™, please join our webinar «Cost-efficient and green manufacturing of peptides thanks to Molecular Hiving technology TM »: you will learn about the scalability and the substantial advantages of this technology regarding efficiency and towards greener manufacturing, as solvent consumption and material requirements are significantly reduced compared to conventional SPPS processes.
About Bachem
The Swiss based Bachem Group is a public, innovation-driven company specializing in the development and manufacturing of pepTides and oligonucleoTides. As a full service provider Bachem offers products for clinical development and commercial applications as well as a comprehensive catalog and exclusive custom synthesis. With 50 years of experience and subsidiaries in Switzerland, the United States, the United Kingdom and Japan, Bachem is the partner of choice for the biotech and pharma industry worldwide.
Bachem. Leading Partner in Tides | www.bachem.com
