Over 50

Chiral Supercritical Fluid Chromatography (SFC) is often the method of choice for a quick delivery of ~100g quantities of the single enantiomer in pre-clinical drug R&D. Resolution techniques (right side of the scheme below), although fast and reliable, have a maximum of 50

Alternatively, the desired single enantiomer compound can be obtained efficiently by chiral pool synthesis or via asymmetric synthesis using a prochiral starting material. Chiral catalysis methods (bio- and chemo-catalysis) are often applied in later stages of the drug development trajectory, when slightly longer timelines allow for route scouting and process development and cost of goods come into play. Symeres has in-house bio- and chemo-catalysis expert teams developing scalable chiral catalytic processes to deliver the single enantiomer. For example, we use commercially available ketoreductases, transaminases, imine reductases, and chiral Ru-complexes, respectively.  

For all chiral technologies, Symeres has the experience to deliver the single enantiomer of choice in high purity and on time.