To combat pollution, a true enemy of the skin, SILAB is offering MITOKINYL®, an anti-pollution natural active ingredient rich in glucomannans and able to combat harmful environmental stress via a unique regulation pathway.
SILAB Research is the first laboratory to identify the central role of mitokines in an optimum antipollution strategy. Thanks to a sophisticated intracellular communication mechanism, these mediators, released by mitochondria under the effects of pollution, connect the skin to its environment and initiate an appropriate anti-stress response.
During a pollution attack, MITOKINYL® :
• regulates the two major biological pathways of pollutant stress response: the synthesis of mitokines (prohibitines) is normalized and the aryl-hydrocarbon receptor is deactivated;
• forms an effective, stratified, functional barrier;
• optimizes complexion tone and radiance in Caucasian and Asian volunteers.
MITOKINYL® protects fragile skin against urban stresses and is recommended in all antipollution facial and body skincare products.
MITOKINYL® restores the mitokines pathway
Study in vitro on SILABSKIN® RE reconstructed epidermis.
Modeling in vitro has shown that stresses resulting from pollution cause a significant reduction in the synthesis of mitokines (prohibitins) by human keratinocytes. This reduction is due to the direct effect of pollutants (benzo[a]pyrene: -12 When subjected to an environment mimicking the consequences of pollution, the synthesis of prohibitin by SILABSKIN® RE is significantly reduced by 28
MITOKINYL® favors the construction of a stratified and functional epidermis
Study in vitro on SILABSKIN® RE reconstructed epidermis.
When faced with a pollution incident, the epidermal construction and the synthesis of epidermal differentiation markers, cytokeratin 10, filaggrin and loricrin, are significantly reduced.
Tested at 0.25
MITOKINYL® revitalizes the recuperation capacity of the skin barrier
Tewameter study in vivo.
MITOKINYL® improves the recuperation capacity of the barrier function of the skin. In only 4 days, MITOKINYL® restores the barrier effect to more than 90
MITOKINYL® inhibits melanogenesis
Study in vitro on cultures of melanocytes.
Tested at 1
MITOKINYL® improves skin complexion
– Complexion radiance and the Caucasian panel
Study in vivo on Caucasian volunteers.
After 14 days of twice daily applications, MITOKINYL®, formulated at 3
MITOKINYL® improves skin complexion
– Chromaticity and the Asian panel
Study in vivo(1) on Asian volunteers.
After 28 days of twice daily applications, MITOKINYL®, formulated at 3
(1) conducted by the Laboratory of Skin Engineering and Biology of the West China Hospital located in the city of Chengdu, Sichuan province, directed by Professor Li Li..
