Composed of natural biopeptides purified to 95%, obtained from the co-product of a superfruit, the cranberry, PEPTILIUM® is a global anti-aging active ingredient. Sustainable and effective, it boosts complexion radiance and attenuates fine lines and wrinkles.
TRANSVERSAL BIOLOGICAL ACTIVITY
Target the three compartments of the skin
Due to their richness and their molecular diversity, the natural biopeptides that make up PEPTILIUM® have the ability to act transversally on several biological targets. The active ingredient thus acts on the various skin compartments:
- it reinforces the epidermal barrier function and boosts complexion radiance [1];
- it improves the quality of the dermal-epidermal junction and of the dermal matrix for an anti-wrinkle action. [2]
A targeted transcriptomic analysis performed by SILAB has also shown that, out of 34 genes involved in skin homeostasis, 76% are deregulated during aging. Thanks to PEPTILIUM®, the expression of 81% of these deregulated genes is normalized.
[1] Tested at 0.5% on aged SILABSKIN® RE reconstructed epidermis, PEPTILIUM® significantly restores keratinocyte proliferation (synthesis of Ki-67: +86%) and differentiation (synthesis of loricrin: +49%), two processes indispensable for renewal of the barrier function.
[2] Tested at 0.1% on aged fibroblasts, PEPTILIUM® significantly increases the production of the collagen I network by 54% and therefore maintains matrix fibers functionally organized.
RAPID AND GLOBAL ANTI-AGING ACTION
Radiance booster and anti-wrinkle
As of 21 days of application, PEPTILIUM® tested at 2% in an emulsion significantly improves the parameters characteristic of complexion radiance in Caucasian (reflection: +12%; pink color: +17%) and Asian subjects (luminosity: +6%; olive color: -5%).
In the same conditions, PEPTILIUM® presents an anti-wrinkle effect in Caucasian (negative volume: -22%) and Asian (stage of crow’s feet wrinkles: -10%) volunteers. These radiance boosting and anti-wrinkle effects intensify after 42 days of treatment and are confirmed by a subjective evaluation: 100% of Caucasian and Asian volunteers consider in particular their fine lines and wrinkles to be attenuated.
A comparative study conducted by SILAB also demonstrates that the efficacy of PEPTILIUM® is more intense and more rapid than that of retinol, while having no side effect.
ADDING VALUE TO A CO-PRODUCT OF A SUPERFRUIT
An upcycling approach
SILAB got interested in a superfruit, the cranberry (Vaccinium macrocarpon). Used by Native Americans in traditional medicine, this small red fruit from North America is today considered to be a health food throughout the world.
In an upcycling approach, SILAB has specifically selected one of its co-products, the cranberry fruit press cake, in particular for its high molecular potential. The company prioritized a supplier committed to practices of sustainable development and developed internally a specific eco-extraction process to produce the natural biopeptides purified to 95%.
PEPTILIUM® (Vaccinium macrocarpon (Cranberry) Fruit Extract) is a patented product, available in aqueous solution (recommended amount: 0.5 to 2%). This active ingredient has a content of natural origin of 99% (ISO 16128) and is compliant with international cosmetic regulations (Europe, United States, Japan, China, etc.).
