Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease with intermittent flares and debilitating effects on the patient’s quality of life. It is the most common skin disorder in children, affecting approximately 15

Vitamin D3 correlate well with synthesis of proteins that are necessary for skin barrier function, these mechanisms suggest a role of 1,25-dihydroxyvitamin D in modulating AD severity. Many researches have investigated difference between 25-dihydroxyvitamin D 25(OH) D levels in AD pediatric patients and matched healthy control. A meta-analysis of these studies found a mean deference of −16 nmol/L in pediatric AD patients compared to healthy control. There is growing interest in the possible role of vit D deficiency in the development of AD. The aggravation of AD in winter, especially in higher-latitude countries, where serum 25(OH)D levels tend to be predominantly low in this season, has been documented. In addition, genetic polymorphisms of the Vit D receptor have been identified as contributor to the development of AD.

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