ANTONIO J. RODRÍGUEZ DÍAZ
RM FARMAMÉDICAL Granada, Spain

Abstract

If an unbalanced oxidative stress is detrimental to health, using an antioxidant that has not demonstrated its pro-oxidant capacity can be even worse for health.
How many antioxidants exist? How many have shown that they are in fact not pro-oxidants at the usual dose? And how do these antioxidants influence the metabolism of an individual? In the Stance4Health project, funded by the European Union’s Horizon 2020 research and innovation program, these situations have been evaluated in vitro and by applying an innovative metabolomics test to urine samples collected on filter paper in humans. Stance4Health, is innovatively applying these research findings to achieve an intelligent personalized nutrition service.

INTRODUCTION
During aerobic cell metabolism, the generation of reactive oxygen species and other free radicals is a normal and necessary process that is generally compensated by endogenous antioxidant defence systems, which help maintain redox balance. When there is an overproduction of reactive oxygen species together with a deficit of enzymatic and non-enzymatic antioxidants, a redox imbalance is produced, which is especially relevant for health.

This state of imbalance is associated with both the normal aging process and numerous diseases (carcinogenesis, cardiovascular disease, hypertension, diabetes, neurodegenerative diseases - Alzheimer’s and Parkinson’s - and rheumatoid arthritis), requiring dietary supplementation of compounds with antioxidant activity, that protect endogenous antioxidants and allow them to carry out their activity against physiologically produced radicals.

The metabolic routes are developed in specific places of our cells, to obtain the best information on the metabolism of an individual, it is necessary to study the metabolic routes, only then will we know how to act to achieve what we ...