Continuous-flow production of alkyl nitrites
JEAN-CHRISTOPHE M. MONBALIU1*, JEREMY JORDA2, BÉRENGÈRE CHEVALIER2, CHRISTIAN V. STEVENS1, BERNARD MORVAN3
*Corresponding author
1. Ghent University, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty ofBioscience Engineering, Coupure links 653, Gent, B-9000, Belgium
2. CORNING S.A.S, Corning European Technology Center, Avenue de Valvins 7 bis, Avon, F-77210, France
3. BIOS Chemicals, Plateforme technologique DELTA Sud, Verniolle, F- 09340, France
Abstract
Alkyl nitrites are important building blocks for the chemicaland pharmaceutical industries. In this article, we reporta case study for the continuous-flow production of alkylnitrites, originally designed by BIOS Chemicals. Theintrinsic advantages of a Corning® Advanced-Flow™reactor system, including high versatility, high mixing, andheat-exchange efficiency under corrosive conditions,allowed the development of an economically viable anduser-friendly process in a short period of time, leading toa throughput of 10t/year of processed material with highpurity (93-98 percent).
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