Abstract

The complex matrix of wine and derived products often makes it necessary to perform extensive sample clean-upprior to the determination of compounds at low levels. Although the combination of liquid chromatography with triplequadrupole mass spectrometry (LC-MS-MS) offers specific data, good sensitivity and eliminates part of the matrix, this sometimesremains insufficient to determine residual compounds. Automated off-line solid-phase extraction (SPE) or liquid-liquid extractioncan be used in combination with LC-MS-MS to meet these specific needs. This paper describes the experimental set-up andapplicability of LC-MS-MS for the determination of biogenic amines, mycotoxins, stilbenes, flavonoids, tannins, anthocyanins andphenolic acids in wine matrices and grape juice.