Resilience is getting more and more important to face the difficulties of recent year and from the nature may come an important help. An ally to manage stress and improve mood is grape (Vitis vinifera), which belongs to family Vitaceae, one of the most highly consumed fruits across the world.

The skin and seeds of grapes are highly rich in polyphenols specifically proanthocyanidins, which can be used as a functional ingredient to address various health issues by boosting the natural bio-processes of the body (1).

Proanthocyanidins are a large family of molecules existing in both monomeric and oligomeric structures up to more than 20 units. Many beneficial properties in cardiovascular, cancer, and neurological disorders as antioxidant, immunomodulatory, antidiabetic, cardio, and neuroprotective agents have long been described and recently reviewed (2).

Grape seeds are the part of the plant with the highest concentration of polyphenols, mainly oligomeric proanthocyanidins (OPCs), which have proven beneficial effects in cardiovascular health thanks to multiple mechanism of action.

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