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INTRODUCTION

Liposomes are artificial membranes, in most cases composed of phospholipids like phosphatidylcholines (PC), phosphatidylethanolamines (PE) and phosphatidylserines (PS), enclosing an aqueous compartment. They form spontaneously when phospholipids are placed in an aqueous environment, because of their dual preference to solvents, which was first described by Bangham and Horne in 1962 (1). Amphiphilic lipids consist of one lipophilic part that is soluble in nonpolar solvents, and a hydrophilic part soluble in polar solvents. Liposomes can be classified according to their structural properties or to their preparation method (2, 3).

An advantage of liposomes as efficient drug delivery systems is the possibility that both hydrophilic and lipophilic ... ...