Figure 1. Pilot column for routine applications.

LC SEPARATIONS ON PILOT SCALE: SUCCESS CRITERIA FOR PACKING QUALITY

Glass chromatography columns for self-packing are often used for LC separations on a pilot scale. For a fast and successful separation, the efficiency of the packed column is essential. An important element of the process is suitable column hardware as the correct hardware can increase the column performance and the cost efficiency of the overall process. Easy and fast column packing is essential for the packing quality and therefore for an efficient process.

The aim of a LC process on a pilot scale is to purify as much product as possible in as short a time as possible as cheaply as possible. An optimum yield is achieved with a high column performance of the packed column. This requires the column bed to be packed efficiently and homogenously.

The selection of suitable column hardware i ... ...