SPEDIA-NMR™: BREAKTHROUGH IN BIOPROCESS OPTIMIZATION FOR BIOLOGICALS
For new biologicals and biosimilars, the innovative Spedia-NMR™ technology from Spinnovation Biologics provides a realadvantage for optimizing cell cultures, monitoring and standardizing manufacturing processes in preparation for larger scaleproduction. Within the past four months, this has been validated by 37 companies developing biologics or delivering servicesto this industry. This premium nuclear magnetic resonance (NMR) analysis service rapidly identifies a wide selection of feedcomponents, metabolites and toxic compounds in culture media. By comparing media profiles from different cell culturebatches, Spedia-NMR™ identifies how a cell consumes and metabolizes the media along the culture process. This allowsthe composition of the media to be fine-tuned to improve cell viability, reach highest yields of biologic product and performrapid process troubleshooting. Spedia-NMR™ technology has gained rapid popularity in both the biotech research andmanufacturing communities because of the speed of analysis (analyse in a matter of minutes/hours, delivery of service withinfive working days) and the valuable information it provides in assisting process development. Dr Frederic Girard the CEO ofSpinnovation said recently about his perception of the value of Spedia-NMR™ to biotech companies: “In the short term,Spedia-NMR™ will fill the gap in knowledge to strengthen and speed up cell culture development and upstreamprocessing […] clients need to know what is going on in their cell culture and they need to know it fast”. Dr Girardthen went on to discuss the mid-term value of services from Spinnovation Biologics: “In the mid-term we will be ableto provide methods and tools to our clients to help them to cope with the demand of FDA edicts regarding Qualityby Design (QbD) and validation in the production environment”. Spedia-NMR™ technology is available on a feefor-sample or as a contract service to all biotech. Users range from medium to large biotech companies and someacademic clients use this specialist service in their protein therapeutics research.
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