P-OP-mediated asymmetric hydrogenation of functionalised alkenes
HÉCTOR FERNÁNDEZ-PÉREZ1, PABLO ETAYO1, JOSÉ L. NÚÑEZ-RICO1, ANTON VIDAL-FERRAN1,2*
*Corresponding author
1. Institute of Chemical Research of Catalonia (ICIQ), Avinguda Països Catalans 16, Tarragona, 43007, Spain
2. Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08010-Barcelona, Spain
Abstract
An enantiomerically pure P-OPligand (phosphine-phosphite)-straightforwardly available from Sharpless epoxy ethers byepoxide ring-opening with a P-nucleophile followed byO-phosphorylation with a P-electrophile- shows an excellentperformance in the Rh-catalysed asymmetric hydrogenationof a wide variety of functionalised alkenes (33 examples).
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