Safe use of azides in continuous flow
ALEXANDER G. O’BRIEN, FRANÇOIS LÉVESQUE, YOSHIKAZU SUZUKI, PETER H. SEEBERGER*
*Corresponding author
Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, Potsdam, 14476, GermanyFreie Universität Berlin, Institute for Chemistry and Biology, Arnimallee 22, 14195 Berlin
Abstract
Continuous flow reactors have diverse applications acrossa broad spectrum of chemical transformations. One keyadvantage is the safe handling of hazardous materials.Azide chemistry is one such area where continuous flowreactors are having significant impact. Here, we describerecent developments in the synthesis and reactivity ofazides, showing that such chemistry can be safely andefficiently performed in continuous flow systems.
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