KEYWORDS: green chemistry, sustainability, reagent selection, reagent optimization, route optimization, reagent development, reagent substitution, reaction workflow, reaction apparatus, designer surfactant, alcohol oxidation, catalyst screening.
ABSTRACT: An analysis is presented on the sluggish adoption of "greener" synthetic technologies relative to older and more established methods that are regarded as less sustainable. This analysis describes how these more sustainable options experience a significant barrier to adoption by chemists because sustainability falls below confidence, cost, difficulty, availability, and quality in the common decision-making priority. A concept is then presented with examples for how this may be partially overcome by the development of more holistic workflow solutions employing sustainable reagents together with robust procedures and apparatus optimized for the best synthetic outcome and sustainable use of resources. This represents a compelling way to advance adoption of new more sustainable synthetic methods in research labs where new methods achieve ado ...
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