Fast Flow peptide synthesis – The route to difficult peptides and scale up

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Oligonucleotides: Right Place, Right time, Right future

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Synthetic Chemistry in Nucleic Acid Drugs Recent progress in bridged nucleic acids (BNA)

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Oligonucleotide therapeutics. A long and windy road towards future medicines

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Peptide Therapeutics 5.0 – Why the significance of peptide-based drugs will grow with the digital shift in drug development and what we must do to unfold this potential

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Efficient and Sustainable Solutions for Large Scale Peptide Manufacturing

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Easy access to purified complex peptides on larger scales with the Peptide Easy Clean Technology – A liraglutide case study

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Downstream Processes for Peptide Manufacturing: optimization strategy and latest technical trends

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Alternative strategies which help improve sustainability and “green” peptide manufacturing

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Transforming oligonucleotide manufacturing

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CMC: Regulatory overview for Oligonucleotide drug substances

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The impact of European pharmacopeia regulations for peptides during the change of manufacturer at late phase

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Green circular economy applied to peptide synthesis

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Peptide chemistry: in-silico development tools for an efficient process design

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Analytical methodologies to assure successful peptide synthesis when utilizing polystyrene/DVB resins

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Solid-phase peptide synthesis: recent advances through adoption of continuous flow

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Peptide manufacturing scale-up: an emerging biotech prospective

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Combining solid phase synthesis and chromatographic purification for efficient peptide manufacture

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Pharmaceutical green chemistry in peptide synthesis – A snapshot on the role of solvents in SPPS

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Next-generation antisense oligonucleotide delivery approaches

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Antisense oligonucleotide-mediated DNM2 targeting in centronuclear myopathies – From preclinical proof of concept towards clinical trials

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The DNA-Based Drug BC 007 neutralizes agonistically acting autoantibodies directed against G protein–coupled receptors – Successful mode of action demonstrated in clinical phase 1 trial

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Technical and regulatory strategies for synthetic peptides

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Tips and tricks in the preparation of anti-peptide antibodies

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Aspects of greening peptide chemistry within the pharmaceutical manufacturing industry

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Improving crude product quality for complex synthetic peptides

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Short arginine analogs: peptide synthesis and prediction of biological effects – Efficient synthesis of peptides containing short analogs of arginine and stability evaluation with docking. Prediction of biological effects of short arginine analogs using computational methods.

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Exploring methods for a difficult coupling

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Therapeutic peptides – What makes them different?

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Development of an efficient purification method for a peptide pharmaceutical – Optimisation of HPLC separation and considerations for scaling up to production scale in case of the GLP-1 receptor agonist liraglutide

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New manufacturing process to produce highly uniform resins with excellent performances in Solid Phase Peptide Synthesis

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Oral peptide therapeutics: Getting easier to swallow?

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